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KMID : 0191120100250071101
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Journal of Korean Medical Science
2010 Volume.25 No. 7 p.1101 ~ p.1104
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A Case of Lewis-Sumner Syndrome Showing Dramatic Improvement after Plasma Exchange
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Park Young-Eun
Yook Ji-Won
Kim Dae-Seong
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Abstract
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We report a patient with Lewis-Sumner syndrome (LSS) who showed an improvement only with plasma exchange (PE). The patient, 32-yr old man, had progressive multifocal motor-sensory deficits with persistent, multiple conduction blocks and marked slowing of NCVs. Nerve pathology supported a diagnosis of demyelinating neuropathy by revealing marked loss of myelinated fibers with inter- and intrafascicular variation. Although the patient was refractory to treatment with corticosteroid and intravenous immunoglobulin, PE produced a dramatic improvement. Our experience strongly proposes that PE should be tried for refractory LSS.
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KEYWORD
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Lewis-Sumner Syndrome, Plasma Exchange, Conduction Block, Nerve Pathology, Cranial Nerve Diseases
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